Loss-of-function mutations in the PINK1 or parkin genes result in recessive heritable forms of parkinsonism.Genetic studies of Drosophila orthologs of PINK1 and parkin indicate that PINK1, a mitochondrially targeted serine/threonine kinase, acts upstream of Parkin, a cytosolic ubiquitin-protein ligase, to promote mitochondrial fragmentation, althou
Nucleic acid sensor elements are proving increasingly useful in biotechnology and biomedical applications.A number of ligand-sensing, conformational-switching 8RP ribozymes (also known as allosteric ribozymes or aptazymes) have been generated by some combination of directed evolution or rational design.Such sensor elements typically fuse a molecula
Abstract Background Road traffic injuries (RTI) are one of the most prominent causes of morbidity and mortality, especially among children and young adults.Motorcycle crashes constitute a significant part of RTIs.Policymakers believe that safety helmets are the single most important protection against motorcycle-related injuries.However, motorcycli
Sexual segregation seems to be common in bottlenose dolphins, whereby males and females live in different pods that mix mainly for mating.Male dolphins often use aggressive behaviour to mate with females, while females with calves may have different activity and DISHWASH LIQUID dietary requirements to males and different susceptibility to predation